Welcome to IJCCI!

The International Journal of Clinical Cases and Investigations, edited by a team of International experts, is a peer reviewed journal that will consider original case reports in the area of diabetes and endocrinology.

Authors are encouraged to invite the patient to contribute to the case report - each article can include an optional 'Patient's perspective' section, where the patient describes their experience of the disorder and treatment.

The articles published in the International Journal of Clinical Cases and Investigations will be submitted for indexing in leading biomedical databases.

Dr. Sanjay Kalra, Editor-in-Chief,

Int J Family Practice; Int J Geriatrics & Gerontology, Bharti Hospital & B.R.I.D.E, Karnal, India

Note: IJCCI is now a quartely publication and new articles will be uploaded on the 1st of April, July, October and January

 
Radiology CME
CT in Pancreatic Trauma Print

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Shahina Bano1, Vikas Chaudhary2

1Department of Radiodiagnosis, PGIMER and Dr. RML Hospital, New Delhi-110001, India.

2Department of Radiodiagnosis, Employees’ State Insurance Corporation (ESIC) Medical College & Hospital, Faridabad-121001, Haryana, India. E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

 

International Journal of Clinical Cases and Investigations. Volume 6 (Issue 5), 58:59, 1st October 2015.


Abstract

Computed tomography (CT) is now the imaging modality of choice for evaluation of abdominal trauma. Pancreatic injuries are difficult to diagnose. CT finding may be subtle and must be actively sought. Parenchymal contusion, lacerations, and hematomas are the most common findings. 

Keywords: Computed tomography, pancreas, pancreatic trauma.


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Case Report
Peripheral Gangrene Due To Secondary Cold Agglutinin Disease Print

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Brijesh Sharma1, Rajnish Singh2, Ramadoss Ramu3, Palden W Bhutia4, Piyush Jain5, Mohammed Ali6, Sangeeta Pahuja7, Geetika Sharma8, R. S. Taneja9.

1,7Associate professor, 2,5Assistant Professor, 3,4Post Graduate, 6,8Senior Resident, 9Professor, This e-mail address is being protected from spambots. You need JavaScript enabled to view it


International Journal of Clinical Cases and Investigations. Volume 6 (Issue 5), 1:5, 1st October 2015.


Abstract

We report a case of a 36 year old man with upper respiratory symptoms and peripheral gangrene on the nose and right toes. He had a history of significant exposure to cold during his illness. Notably, his initial blood sample for the hemogram was reported clotted even after proper collection. Further evaluation showed the features of autoimmune haemolytic anemia due to cold agglutinins secondary to Mycoplasma and EBV infections. Hemolysis and Raynaud’s phenomenon are common manifestations of secondary cold agglutinin disease (CAD), but gangrene is rare. This case is reported for the exceptional presentation of secondary CAD with peripheral gangrene.

 

Keywords: Gangrene, Cold agglutinin, Hemolytic Anemia, Mycoplasma Pneumoniae, Epstein Barr Virus

 

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Review Article
Oral manifestations in renal disease and its related complications Print

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Shikha Handa1, Ginnia Bhayana2, Gaurav Atreja3.

1Sr Lecturer, Department Of Pedodontics, MM College of dental science and research, Mullana, 2Demonstrator, Department of Prosthodontics, Govt dental college Rohtak, 3Reader, Department of Prosthodontics, MM College of dental science and research, Mullana. Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it


International Journal of Clinical Cases and Investigations. Volume 6 (Issue 5), 6:12, 1st October 2015.

 

Abstract

The systemic condition of patients with kidney failure has oral manifestations and specific implications for dental treatment. Dental problems may compromise the patient’s general health and hinder medical efforts to either maintain or replace vital kidney functions. Specifically, the dentist must consider bleeding tendency, risk of infection and medications before treating the patient. Oral and dental health has served as a valuable indicator in measuring the prognosis of chronic kidney disease, while, its role in diagnosing renal pathosis requires to be explored further. Consultation with the nephrologist is essential before any dental treatment is carried out, in order to determine the condition of the patient, define the best moment for dental treatment, introduce the necessary pharmacological adjustments, or to establish other important aspects for preventing complications in the dental clinic. This manuscript reviews the characteristics of the disease, the existing therapeutic options, and the considerations of relevance for the dental professional.

 

Keywords: Kidneys, Chronic renal disease, Dental Management 

 

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Case Report
Unicystic ameloblastoma in mandible: focus on differential diagnosis, FNAC and radiographic features Print

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Pooja Soni1, Gaurav Sharma2, Keerthilata M. Pai3, Kundendu A. Bishen4

1Resident associate, AHEAD academy, New Delhi, 2Reader,Department of Oral medicine and radiology, S.R. Dental college, Faridabad, Haryana,. 3Prof. and Head, Department of Oral medicine and radiology, MCODS, Manipal, Karnataka, Bishen, 4Department of Oral Pathology, Jodhpur dental college, Jodhpur, Rajasthan, India. Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

 

International Journal of Clinical Cases and Investigations. Volume 6 (Issue 5), 13:21, 1st October 2015.


Abstract

Unicystic ameloblastoma (UA) represents cystic conditions that demonstrates clinico- radiographic attributes of an odontogenic cyst but on a histopathological examination displays a characteristic ameloblastomatous epithelium lining as a component of the cystic cavity.UA is less aggressive, affects younger age-group patients and typically has a favourable response to therapeutic modalities. The authors present a rare case of UA observed in a 35 year old female patient and emphasize the importance of Fine Needle Aspiration Cytology (FNAC). The purpose of writing this article is to illustrate the differential diagnosis of swelling with a unilocular radiolucency in mandible 

 

Keywords: Unicystic ameloblastoma; differential diagnosis; FNAC 

 

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Case Report
Cubitus rectus: A skeletal marker of 48, XXXY karyotype Print

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Partha Pratim Chakraborty,1 Rana Bhattacharjee,2 Sujoy Ghosh,3 Satinath Mukhopadhyay,4 Subhankar Chowdhury.5

1Assistant Professor, Department of Medicine, Midnapore Medical College & Hospital; Midnapore; West Bengal; India. 2RMO-cum-clinical tutor, 3Associate Professor, 4,5 Professor, Department of Endocrinology & Metabolism, IPGME&R/SSKM Hospital; Kolkata; West Bengal; India. Email:  This e-mail address is being protected from spambots. You need JavaScript enabled to view it


International Journal of Clinical Cases and Investigations. Volume 6 (Issue 5), 22:25, 1st October 2015.


Abstract

48, XXXY syndrome is a rare disorder of sex chromosomal aneuploidy. Clinically they are almost indistinguishable from the classical 47, XXY Klinefelter's syndrome. Cubitus rectus, defined as absence of carrying angle is a unique feature of this rare syndrome. We describe a patient with hypergonadotrophic hypogonadism, who presented with bilateral cubitus rectus and intellectual imapairment suggestive of underlying 48, XXXY karyotype.

 

Keywords: 48, XXXY syndrome, 47, XXY syndrome, Klinefelter's syndrome, Cubitus rectus

 

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Case Report
Tooth extraction socket and site preservation prior for future dental implant treatment. Print

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Swaminathan Rajendran,1 Raghunathan Jagannathan,2 Venkatakrishnan C J.3

1,2Consultant Periodontist, VK's Dental Care, 3Research Scholar (Prosthodontology)

Bharath University, Tamilnadu, India.  Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it


International Journal of Clinical Cases and Investigations. Volume 6 (Issue 5), 26:31, 1st October 2015.

 

Abstract

The alveolar bone will decrease in volume both height, width and change morphologically following tooth extraction. The consequence of which makes it clinically challenging for tooth replacement by a conventional bridge or dental implant. Recent advances in bone grafting materials and techniques allow the dentist to place implants in sites that were considered compromised in the past. Aesthetics is an integral part of implant therapy. The aim of this article is to evaluate the effect of socket preservation in terms of bone fill following tooth extraction. This case report describes socket preservation procedure performed prior to placement of an endosseous dental implant. The first molar tooth on the lower right side was extracted due to failure of endodontic treatment due to perforation. Following extraction the socket was filled withhydroxyapatite bone graft and resorbable membrane was used to close the socket. The radiographic assessment of the site 6 months post operative revealed satisfactory bone fill.

 

Keywords: alveolar bone resorption, tooth extraction, bone graft

 

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Case Report
Rare Presentation of Edward Syndrome with Mesocardia Print

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Srinivas Madoori1, Sandeep G2, Sreenivas Kotla2, Anitha chikati2, Radhika K2.

1 Professor, 2Resident, Department of Pediatrics, Chalmeda Anand Rao Institute Of Medical Sciences, Telangana, India.

 Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

 

International Journal of Clinical Cases and Investigations. Volume 6 (Issue 5), 32:38, 1st October 2015.

 

Abstract

Edward syndrome is a chromosomal numerical disorder caused by the presence of all or part of an extra 18th chromosome. It is characterized by cardiac, renal, gastrointestinal tract and skeletal malformations. Here we report a case of a neonate admitted with increased work of breathing since birth. He had multiple congenital anomalies. On echocardiogram, mesocardia with atrial septal defect found, which is a rare presentation.

 

Keywords: Edward syndrome, mesocardia, rocker bottom feet.

 

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Review Article
Anatomical Diversification Of Soft Palate: A Clinico-Radiological Overview Print

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Tanya Khaitan,1 Arpita Kabiraj,2 Uday Ginjupally,3 Ramaswamy P4

1,Senior lecturer, Department of Oral Medicine & Radiology, Haldia institute of dental sciences and research, 2Senior lecturer, Department of Oral Pathology & Microbiology, Haldia, West Bengal, 3Senior lecturer, Department of Oral Medicine & Radiology, Kameneni institute of dental sciences, Narketpally, Andhra Pradesh, 4Professor & Head, Department of Oral Medicine & Radiology, St. Joseph Dental College & Hospital, Eluru, Andhra Pradesh, India. Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it


International Journal of Clinical Cases and Investigations. Volume 6 (Issue 5), 39:45, 1st October 2015.


Abstract

Soft palate (velum) represents the posterior fibro-muscular portion of the palate. Its dimensions and active relations participate in most of the oral functions, particularly in velopharyngeal closure which is associated with the normal functions of sucking, swallowing, respiration, phonation and pronunciation. This also helps to control nasal airflow and any disturbance in this mechanism may cause problems in phonation. Such disorders may include obstructive sleep apnoea, cleft palate, malocclusion and oral submucous fibrosis. The anatomical and radiological correlation of the velum may aid in the research of the velopharyngeal closure and etiological study of these conditions.


Keywords: Anatomy; Velum; Obstructive sleep apnoea; Cleft; Oral submucous fibrosis.

 

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Original Research
Study On Aetiopathology Of Ulcers And Membranous Lesions Of Oral Cavity And Oropharynx Print

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Hadi Khorram,1 Sreenivasa Rao Sudulagunta,2 Shyamala Krishnaswamy Kothandapani,3 Mahesh Babu Sodalagunta,4 Mona Sepehrar,5 Zahra Noroozpour.6

1Otolaryngology department, Dr. B.R. Ambedkar Medical College Hospitalist, Columbia Asia Hospital, Assistant professor, Dr.B.R.Ambedkar Medical College, 3Pulmonologist. Assistant Professor, Dr.B.R.Ambedkar Medical College, 4Post Graduate in General Medicine, KS.Hegde Medical College, 5 This e-mail address is being protected from spambots. You need JavaScript enabled to view it

International Journal of Clinical Cases and Investigations. Volume 6 (Issue 5), 46:53, 1st October 2015.


Abstract

Oral cancer ranks in the top three of all cancers in India, age adjusted rates of oral cancer in India is 20 per 100,000 population and accounts for over 30% of all cancers in the country. Early detection of oral lesions will improve the cure rate, and also lowers the cost and morbidity associated with treatment. Data from 300 patients who are histopathologically diagnosed with oral lesions was analyzed for aetiopathological factors from Jan 2012 to Jan 2015. Out of 300 patients 48 %( 144) were female and 52 %( 156) were male. Mean age of patients was 28.88 years, with almost 75% between 15 and 35 years. Duration of symptoms varied from 1 day to 12 months. 86% patients belonged to low socio economic status and 78 %patients consumed non vegetarian diet. 86% patients practiced the habit of tobacco use (47% smoking and 74% Tobacco chewing) and 10% had betel nut chewing habit. Alcohol consumption was found in 47% of patients. Poor oral hygiene was present in 86% of patients. Pre malignant conditions were found in 28% of patients, chronic traumatic irritation in 21% of patients and Iron deficiency anemia was found in 10% of patients. Most common site of the oral cancer was the tongue (33%). Tobacco and alcohol intake, iron deficiency anemia, chronic traumatic irritation and poor oral hygiene seem to be the most important etiological factors in the development of oral and oropharyngeal malignancy.

Keywords: Cross sectional study, Tobacco usage, pre malignant lesions, Anemia

 

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Original Research
Parry Romberg Syndrome:an uncommon clinical entity Print

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Sugata Narayan Biswas,1 Partha Pratim Chakraborty,2 Rana Bhattacharjee3

1,2Department of Medicine,   , Midnapore Medical College, 3Department of Endocrinology, Institute of Post Graduate Medical Education & Research And SSKM Hospital, West Bengal, India Email:  This e-mail address is being protected from spambots. You need JavaScript enabled to view it

 

International Journal of Clinical Cases and Investigations. Volume 6 (Issue 5), 54:57, 1st October 2015.

 

Abstract

Two patients, an 18-year-old female and a 24-year-old male presented to us with complaints of slowly progressive right hemifacial atrophy. Both patients denied any history of seizures, headache, visual disturbances, facial pain, trauma or similar lesions in their respective families. Physical examination of both revealed paramedian hyperpigmented ridges on forehead suggestive of en coup de sabre, unilateral hemifacial atrophy and loss of hair of right eyebrows.Biopsy from lesional skin in both cases demonstrated atrophic epidermis,flattening of rete ridges and thickened dermis with abundant collagen,suggestive of Parry Romberg syndrome. Parry Romberg Syndrome(PRS) is characterized by progressive yet self-limiting hemifacial atrophy of mainly skin and subcutaneous tissue with variable atrophy of muscles,cartilage and bone. En coup de sabre and PRS, believed to be a subtype of localized scleroderma are frequently coexistent.

 

Keywords: progressive hemifacial atrophy, Parry Romberg Syndrome, en coup de sabre

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Radiology CME
Imaging in Intraductal Papillary Mucinous Neoplasm of the Pancreas Print

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Shahina Bano1, Vikas Chaudhary2

1Department of Radiodiagnosis, PGIMER and Dr. RML Hospital, New Delhi, India

2Department of Radiodiagnosis, Employees’ State Insurance Corporation (ESIC) Medical College & Hospital, Faridabad-121001, Haryana, India.

E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it


International Journal of Clinical Cases and Investigations. Volume 6 (Issue 4), 1:2, 1st July 2015.


Keywords: ERCP, Intraductal papillary mucinous neoplasm, MRCP, magnetic resonance imaging, pancreas, pancreatic neoplasm.


Intraductal papillary mucinous neoplasms (IPMNs) of pancreas are cystic tumors of pancreas arising from the main pancreatic duct or its major branches. They can also present as a combination of the branch and main duct type. IPMN accounts for 1% of all exocrine pancreatic tumors. Males are more commonly affected between the ages of 60 and 80 years. Clinical presentation includes recurrent abdominal pain, diarrhea, weight loss and diabetes mellitus.1,2

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